Remedy · supplement
SAM-e
Also: S-adenosylmethionine, SAMe
A naturally occurring molecule sold as a supplement for joint pain and mood, with inconclusive OA evidence.
Evidence by condition
Each grade reflects the research for SAM-e and that condition specifically.
- —Knee osteoarthritis
Some small trials suggest pain relief comparable to NSAIDs, but the evidence is too low-quality to confirm a benefit.
1 citation
- S-Adenosylmethionine for osteoarthritis of the knee or hip Systematic review 2009 · n=656 · Cochrane Database of Systematic Reviews · DOI 10.1002/14651858.CD007321.pub2
- S-Adenosylmethionine for osteoarthritis of the knee or hip