Safety
Interaction & safety checker
Add the herbs, supplements, and drugs you take. We flag recorded interactions, duplicate active compounds, and combinations that pile up the same kind of risk — the herb-and-drug check that’s usually locked behind a clinical paywall.
Your stack is empty. Add two or more items to check for interactions.
Checks
Add at least two items to check.
Where the interaction data comes from
Every remedy page in Materia carries a hand-curated safety block and a
typed interactsWith list. The checker runs entirely on that data — it
is not a third-party API call. Specifically, the checker knows about three things:
- Pairwise interactions. Each
interactsWithentry names a target remedy, a severity (severe / moderate / minor / theoretical), and a plain-language mechanism. These are drawn from the cited sources on each remedy page — NCCIH fact sheets, MedlinePlus drug records, MSK About Herbs monographs, and primary studies where the interaction was characterized. - Duplicate active compounds. When two products in your stack share a compound (e.g. two different “sleep aids” both containing melatonin), the checker flags the overlap so you don’t accidentally double-dose a constituent.
- Risk-class clustering. The checker infers risk classes (bleeding, sedation, serotonin, blood sugar, blood pressure, CYP/P-gp) from the free-text interaction notes on each remedy and warns when several items in your stack pile onto the same system — even when no single pair has a recorded interaction.
The full interaction graph is also available as machine-readable JSON via the
knowledge-graph export (remedy-interacts-with
edges). The checker is a read-only view of that same data.
This tool aggregates the interactions recorded in our cited sources and is not exhaustive — it cannot replace a pharmacist or clinician, who can check your full medication list and conditions. Interaction databases change; always verify time-sensitive decisions with a qualified professional.